Publications
Conrad, D.M., A.L. Hilchie, K.A.M. McMillan, R.S. Liwski, D.W. Hoskin and M.R. Power Coombs. The acute phase protein hepcidin is cytotoxic to human and mouse myeloma cells. Anticancer Research. 2021; 41:601-608.
McMillan, K.A.M., M.R. Power Coombs. Examining the Natural Role of Amphibian Antimicrobial Peptide Magainin. Molecules. 2020; 25(22):5436.
Hilchie, A.L., E.E. Gill, M.R. Power Coombs, R. Falsafi, R.E.W. Hancock, and D.W. Hoskin. MDA- MB-231 breast cancer cells resistant to pleurocidin-family lytic peptides are chemosensitive and exhibit reduced tumor-forming capacity. Biomolecules. 2020; 10(9):1220.
Power Coombs, M.R. and D.W. Hoskin. Assessing the impact of phytochemicals on immune checkpoints: Implications for cancer immunotherapy. Methods Mol. Biol. 2020; 2111:161-173.
Greenshields, A.L., M.R. Power Coombs, W. Fernando, B.E. Holbein and D.W. Hoskin. DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth by promoting S-phase DNA damage. BioMetals. 2019; Dec;32(6):909-921.
Hilchie, A.L., D.W. Hoskin and M.R. Power Coombs. Anticancer activities of natural and synthetic peptides. Springer Nature Singapore Pte Ltd. Book: “Antimicrobial peptides, advances in experimental medicine and biology.” 2019; 1117:131-47.
Furlong, S., M.R. Power Coombs, J. Ghassemi Rad and D.W. Hoskin. Thy-1 (CD90) signaling preferentially promotes RORγt expression and a Th17 response. Front. Cell Dev. Biol. 2018 Nov 6:158.
Furlong, S., M.R. Coombs and D.W. Hoskin. Thy‐1 stimulation of mouse T cells induces a delayed T cell receptor‐like signal that results in Ca2+‐independent cytotoxicity. Mol. Med. Rep. 2017 Oct;16(4):5683-92.
Fernando, W., M.R. Coombs, D.W. Hoskin and H.P. Rupasinghe. Docosahexaenoic acid-acylated phloridzin, a novel polyphenol fatty acid ester derivative, is cytotoxic to breast cancer cells. Carcinogenesis. 2016 Oct;37(10):1004-13.
Power Coombs, M.R.+, M.E. Harrison+ and D.W. Hoskin. Apigenin inhibits the inducible expression of programmed death ligand 1 by mammary carcinoma cells. Cancer Lett. 2016 Oct 1;380(2):424-33. +These authors contributed equally to this work.
Bernard, M., S. Furlong, M.R. Power Coombs and D.W. Hoskin. Differential inhibition of T lymphocyte proliferation and cytokine synthesis by [6]-gingerol, [8]-gingerol, and [10]-gingerol. Phytother Res. 2015 Nov 29(11):1707-13.
Power Coombs, M.R., T. Grant, A.L. Greenshields, D.J Arsenault, B. Holbein and D.W. Hoskin. Inhibitory effect of iron withdrawal by chelation on the growth of human and murine mammary carcinoma and fibrosarcoma cells. Exp. Mol. Pathol. 2015 Oct;99(2):262-70.
Yaffe, P.B., M.R. Power Coombs, C.D. Doucette, M. Walsh and D.W. Hoskin. Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress. Mol. Carcinog. 2015 Oct;54(10):1070-85.
Madera, L., M.R. Power Coombs, A.L. Greenshields and D.W. Hoskin. 4T1 murine mammary carcinoma cells enhance macrophage-mediated innate inflammatory responses. PLoS One. 2015 Jul 15;10(7):e0133385.
McDonald M., M. Mannion, D. Pike, K. Lewis, A. Flynn, A.M. Brannan, M.J. Browne, D. Jackman, L. Madera, M.R. Power Coombs, D.W. Hoskin, M.L. Rise and V. Booth. Structure-function relationships in histidine-rich antimicrobial peptides from Atlantic cod. Biochim Biophys Acta. 2015 Apr 1;1848(7):1451-61.
Harrison, M.E., M.R. Power Coombs, L.M. Delaney and D.W. Hoskin. Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt. Exp. Mol. Pathol. 2014 Jul 12;97(2):211-17.
Power Coombs, M.R., K.D. Kronforst and O. Levy. Neonatal host defense against staphylococcal infections. Clin. Dev. Immunol. 2013; 2013:826303.
Hilchie, A.L., D.M. Conrad, M.R. Power Coombs, T. Zemlak, C.D. Doucette, R.S. Liwski and D.W. Hoskin. Pleurocidin-family cationic antimicrobial peptides mediate lysis of multiple myeloma cells and impair the growth of multiple myeloma xenografts. Leuk. Lymphoma. 2013; Oct;54(10):2255-62.
Hilchie, A.L.*, M.R. Power Coombs* and D.W. Hoskin. Obstacles and solutions to the use of cationic antimicrobial peptides in the treatment of cancer. ACS Books. Book: "Small wonders: Peptides for disease control." 2012; 1095:61-78. *These authors contributed equally to this work.
Kronforst, K.D., C.J. Mancuso, M. Pettengill, J. Ninkovic, M.R. Power Coombs, C. Stevens, M. Otto, C. Mallard, X. Wang, D. Goldmann and O. Levy. A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses. PLoS One. 2012; 7(9):e43897.
Conrad, D.M.*, M.R. Power Coombs*, S.J. Furlong, N.A. Forward and D.W. Hoskin. Induction of CD4+CD25+Foxp3- regulatory T cells by Thy-1 stimulation of CD4+ T cells. Immunol. Cell Biol. 2012; 90(2):248-52. *These authors contributed equally to this work.
Forward, N.A., D.M. Conrad, M.R. Power Coombs, C.D. Doucette, S.J. Furlong, T.J. Lin and D.W. Hoskin. Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling. Biochem. Biophys. Res. Commun. 2011; 407(4):801-6.
Power Coombs, M.R., M.E. Belderbos, L.C. Gallington, L. Bont and O. Levy. Adenosine modulates Toll-like receptor function: Basic mechanisms and translational opportunities. Expert Rev. Anti Infect. Ther. 2011; 9(2):261-9.
Strunk, T.*, M.R. Power Coombs*, A.J. Currie, P. Richmond, D.T. Golenbock, L. Stoler-Barak, L.C. Gallington, M. Otto, D. Burgner and O. Levy. TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. PLoS One. 2010; 5(4):e10111. *These authors contributed equally to this work.
Power, M.R., M. Yamamoto, S. Akira and T.J. Lin. Toll-IL-1 receptor domain-containing adapter-inducing IFN-b is required for the clearance of Gram-negative bacterium Pseudomonas aeruginosa from the mouse lung. J. Immunol. 2007; 178(5):3170-6.
Jenkins, C.E., A. Swiatoniowski, M.R. Power and T.J. Lin. Pseudomonas aeruginosa induced human mast cell apoptosis is associated with up-regulation of endogenous Bcl-xS and down-regulation of Bcl-xL. J. Immunol. 2006; 177(11):8000-7.
Power, M.R., J.S. Marshall, M. Yamamoto, S. Akira and T.J. Lin. The myeloid differentiation factor 88-independent pathway is sufficient for the development of delayed host response to Pseudomonas aeruginosa lung infection in mice. Clin. Exp. Immunol. 2006; 146(2):323-9.
Li, B., M.R. Power and T.J. Lin. De novo synthesis of early growth response factor-1 is required for the full responsiveness of mast cells to produce TNF and IL-13 by IgE + antigen stimulation. Blood. 2006; 107(7):2814-20.
Peng, Y., M.R. Power, B. Li and T.J. Lin. Inhibition of IKK down-regulates antigen + IgE induced TNF production by mast cells: A role for IKK-IkB-NF-kB pathway in IgE-dependent mast cell activation. J. Leukoc. Biol. 2005; 77(6):975-83.
Kralovec, J.A., M.R. Power, F. Liu, E. Maydanski, S.H. Ewart, L.V. Watson, C.J. Barrow and T.J. Lin. An aqueous chlorella extract inhibits IL-5 production by mast cells in vitro and reduces ovalbumin-induced eosinophil infiltration in the airway in mice in vivo. Int. Immunopharmacol. 2005; 5(4):689-98.
Power, M.R., Y. Peng, E. Maydanski, J.S. Marshall and T.J. Lin. The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice. J. Biol. Chem. 2004; 279(47):49315-22. (Addition and Correction in: J. Biol. Chem. 2005; 280(3):2395-6.
McMillan, K.A.M., M.R. Power Coombs. Examining the Natural Role of Amphibian Antimicrobial Peptide Magainin. Molecules. 2020; 25(22):5436.
Hilchie, A.L., E.E. Gill, M.R. Power Coombs, R. Falsafi, R.E.W. Hancock, and D.W. Hoskin. MDA- MB-231 breast cancer cells resistant to pleurocidin-family lytic peptides are chemosensitive and exhibit reduced tumor-forming capacity. Biomolecules. 2020; 10(9):1220.
Power Coombs, M.R. and D.W. Hoskin. Assessing the impact of phytochemicals on immune checkpoints: Implications for cancer immunotherapy. Methods Mol. Biol. 2020; 2111:161-173.
Greenshields, A.L., M.R. Power Coombs, W. Fernando, B.E. Holbein and D.W. Hoskin. DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth by promoting S-phase DNA damage. BioMetals. 2019; Dec;32(6):909-921.
Hilchie, A.L., D.W. Hoskin and M.R. Power Coombs. Anticancer activities of natural and synthetic peptides. Springer Nature Singapore Pte Ltd. Book: “Antimicrobial peptides, advances in experimental medicine and biology.” 2019; 1117:131-47.
Furlong, S., M.R. Power Coombs, J. Ghassemi Rad and D.W. Hoskin. Thy-1 (CD90) signaling preferentially promotes RORγt expression and a Th17 response. Front. Cell Dev. Biol. 2018 Nov 6:158.
Furlong, S., M.R. Coombs and D.W. Hoskin. Thy‐1 stimulation of mouse T cells induces a delayed T cell receptor‐like signal that results in Ca2+‐independent cytotoxicity. Mol. Med. Rep. 2017 Oct;16(4):5683-92.
Fernando, W., M.R. Coombs, D.W. Hoskin and H.P. Rupasinghe. Docosahexaenoic acid-acylated phloridzin, a novel polyphenol fatty acid ester derivative, is cytotoxic to breast cancer cells. Carcinogenesis. 2016 Oct;37(10):1004-13.
Power Coombs, M.R.+, M.E. Harrison+ and D.W. Hoskin. Apigenin inhibits the inducible expression of programmed death ligand 1 by mammary carcinoma cells. Cancer Lett. 2016 Oct 1;380(2):424-33. +These authors contributed equally to this work.
Bernard, M., S. Furlong, M.R. Power Coombs and D.W. Hoskin. Differential inhibition of T lymphocyte proliferation and cytokine synthesis by [6]-gingerol, [8]-gingerol, and [10]-gingerol. Phytother Res. 2015 Nov 29(11):1707-13.
Power Coombs, M.R., T. Grant, A.L. Greenshields, D.J Arsenault, B. Holbein and D.W. Hoskin. Inhibitory effect of iron withdrawal by chelation on the growth of human and murine mammary carcinoma and fibrosarcoma cells. Exp. Mol. Pathol. 2015 Oct;99(2):262-70.
Yaffe, P.B., M.R. Power Coombs, C.D. Doucette, M. Walsh and D.W. Hoskin. Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress. Mol. Carcinog. 2015 Oct;54(10):1070-85.
Madera, L., M.R. Power Coombs, A.L. Greenshields and D.W. Hoskin. 4T1 murine mammary carcinoma cells enhance macrophage-mediated innate inflammatory responses. PLoS One. 2015 Jul 15;10(7):e0133385.
McDonald M., M. Mannion, D. Pike, K. Lewis, A. Flynn, A.M. Brannan, M.J. Browne, D. Jackman, L. Madera, M.R. Power Coombs, D.W. Hoskin, M.L. Rise and V. Booth. Structure-function relationships in histidine-rich antimicrobial peptides from Atlantic cod. Biochim Biophys Acta. 2015 Apr 1;1848(7):1451-61.
Harrison, M.E., M.R. Power Coombs, L.M. Delaney and D.W. Hoskin. Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt. Exp. Mol. Pathol. 2014 Jul 12;97(2):211-17.
Power Coombs, M.R., K.D. Kronforst and O. Levy. Neonatal host defense against staphylococcal infections. Clin. Dev. Immunol. 2013; 2013:826303.
Hilchie, A.L., D.M. Conrad, M.R. Power Coombs, T. Zemlak, C.D. Doucette, R.S. Liwski and D.W. Hoskin. Pleurocidin-family cationic antimicrobial peptides mediate lysis of multiple myeloma cells and impair the growth of multiple myeloma xenografts. Leuk. Lymphoma. 2013; Oct;54(10):2255-62.
Hilchie, A.L.*, M.R. Power Coombs* and D.W. Hoskin. Obstacles and solutions to the use of cationic antimicrobial peptides in the treatment of cancer. ACS Books. Book: "Small wonders: Peptides for disease control." 2012; 1095:61-78. *These authors contributed equally to this work.
Kronforst, K.D., C.J. Mancuso, M. Pettengill, J. Ninkovic, M.R. Power Coombs, C. Stevens, M. Otto, C. Mallard, X. Wang, D. Goldmann and O. Levy. A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses. PLoS One. 2012; 7(9):e43897.
Conrad, D.M.*, M.R. Power Coombs*, S.J. Furlong, N.A. Forward and D.W. Hoskin. Induction of CD4+CD25+Foxp3- regulatory T cells by Thy-1 stimulation of CD4+ T cells. Immunol. Cell Biol. 2012; 90(2):248-52. *These authors contributed equally to this work.
Forward, N.A., D.M. Conrad, M.R. Power Coombs, C.D. Doucette, S.J. Furlong, T.J. Lin and D.W. Hoskin. Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling. Biochem. Biophys. Res. Commun. 2011; 407(4):801-6.
Power Coombs, M.R., M.E. Belderbos, L.C. Gallington, L. Bont and O. Levy. Adenosine modulates Toll-like receptor function: Basic mechanisms and translational opportunities. Expert Rev. Anti Infect. Ther. 2011; 9(2):261-9.
Strunk, T.*, M.R. Power Coombs*, A.J. Currie, P. Richmond, D.T. Golenbock, L. Stoler-Barak, L.C. Gallington, M. Otto, D. Burgner and O. Levy. TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. PLoS One. 2010; 5(4):e10111. *These authors contributed equally to this work.
Power, M.R., M. Yamamoto, S. Akira and T.J. Lin. Toll-IL-1 receptor domain-containing adapter-inducing IFN-b is required for the clearance of Gram-negative bacterium Pseudomonas aeruginosa from the mouse lung. J. Immunol. 2007; 178(5):3170-6.
Jenkins, C.E., A. Swiatoniowski, M.R. Power and T.J. Lin. Pseudomonas aeruginosa induced human mast cell apoptosis is associated with up-regulation of endogenous Bcl-xS and down-regulation of Bcl-xL. J. Immunol. 2006; 177(11):8000-7.
Power, M.R., J.S. Marshall, M. Yamamoto, S. Akira and T.J. Lin. The myeloid differentiation factor 88-independent pathway is sufficient for the development of delayed host response to Pseudomonas aeruginosa lung infection in mice. Clin. Exp. Immunol. 2006; 146(2):323-9.
Li, B., M.R. Power and T.J. Lin. De novo synthesis of early growth response factor-1 is required for the full responsiveness of mast cells to produce TNF and IL-13 by IgE + antigen stimulation. Blood. 2006; 107(7):2814-20.
Peng, Y., M.R. Power, B. Li and T.J. Lin. Inhibition of IKK down-regulates antigen + IgE induced TNF production by mast cells: A role for IKK-IkB-NF-kB pathway in IgE-dependent mast cell activation. J. Leukoc. Biol. 2005; 77(6):975-83.
Kralovec, J.A., M.R. Power, F. Liu, E. Maydanski, S.H. Ewart, L.V. Watson, C.J. Barrow and T.J. Lin. An aqueous chlorella extract inhibits IL-5 production by mast cells in vitro and reduces ovalbumin-induced eosinophil infiltration in the airway in mice in vivo. Int. Immunopharmacol. 2005; 5(4):689-98.
Power, M.R., Y. Peng, E. Maydanski, J.S. Marshall and T.J. Lin. The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice. J. Biol. Chem. 2004; 279(47):49315-22. (Addition and Correction in: J. Biol. Chem. 2005; 280(3):2395-6.